促红细胞生成素对大鼠创伤性脑损伤保护作用的研究

bstract: Objective: To explore the effectiveness of erythropoietin administration on blood-brain barrier, brain edema, injury volume and Neuron-specific enolase levels in serum after traumatic brain injury in rats. Methods: Experimental traumatic brain injury was induced in rats by a weigth-drop model. 48 hours after injury extent of blood-brain barrier breakdown，brain water content，injury volume and 24hours after Neuron-specific enolase in serum was measured .Results: blood-brain barrier breakdown was lower in erythropoietin group than in the control group. Brain edema was reduced in the erythropoietin group relative to the control group. Erythropoietin treatment reduced injury volume compared with control group. Neuron-specific enolase levels of serum is lower in erythropoietin group than in the control group. Conclusions: Administration of erythropoietin reduced blood-brain barrier permeability, injury volume,brain edema and neuron damage.