银屑病患者皮肤中原位记忆T细胞的检测

Objective To investigate the role of tissue-resident memory T cells in the pathogenesis of psoriasis. Methods These cinical informations, lesions and nonlesions were collected from 32 patients with plaque psoriasis. After deflorescence, skin specimens were obtained from 9 patients with psoriasis. 10 normal human skin specimens were as controls. The two characteristic surface marks CD69 and CD103 on tissue-resident memory T cells were detected by immunohistochemical staining to analysing the status in different stage of psorisis. Results The numbers of CD69+CD103+T cells in lesions are more than that in nonlesions of psoriasis significantly (P＜0.05). There aren't significantly different in the numbers of CD69+CD103+T cells between psoriatical lesions and these skin specimens of recovery (P＞0.05). The numbers of CD69+CD103+T cells in normal controls are less than that in nonlesions of psoriasis (P＜0.05). Conclusions The tissue-resident memory T cells may play a role in formation and relapse of lesions in psoriasis.