3,4-二氢-1,8-萘啶酮类化合物的高效合成

1,8-Naphthyridine derivatives are important heterocyclic compounds which has special biological and chemical property. We reported herein the synthesis of 3-alkenyl-2-aminopyridines via Rh-catalyzed C-H olefination of the C3 position of pyridines. Subsequently, a series of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been prepared from 3-alkeny pyridines in one pot via two steps, including catalytic hydrogenation and intramolecular cyclization. This protocol proceeded under mild reacton conditions and was operationally simple.