四妙勇安汤对实验性动脉粥样硬化模型兔血清ox-LDL、NO及MPO影响的研究

Objective Observation of Simiao Yongan Decoction on rabbits atherosclerosis (AS) and to explore the formation of plaque formation of AS and its prevention mechanisms.Mehods 56 male Japanese rabbits were randomly divided into normal group, model group, simvastatin group and Simiao Yongan Decoction group, in addition to the normal group, other groups to establish aortic atherosclerotic plaque model, from the experiment 1st day to the corresponding drug intervention began, 10 were killed over the weekend after the admission of narcotic aortic line by HE staining Pathomorphological observation and experimental dynamic 0,3,6,10 weeks serum lipids, ox_LDL, MPO and NO, etc. content. Results Pathology observed that the apparent thickening of intima, the model group intimal / medial thickness ratio (IT / MT)> 1.8, the treatment group than in model group lesions light and there is statistical significance; simvastatin Jiangzhi role its early stages than Simiao Yongan Decoction, and in the late model 6,10 week in lowering of the ox-LDL and promote NO release at Simiao Yongan Decoction superior to simvastatin, 10 weeks when the serum levels of MPO group have no statistical significance. Conclusion Simiao Yongan Decoction can reduce blood fat and ox-LDL levels, raise the serum NO content and its prevention AS plaque formation mechanism and anti-inflammatory, anti-oxidative stress reaction effects.