KLF4蛋白结构与功能
Structure and Function of KLF4
Sp1样蛋白（Sp1-like proteins）和Krüppe样因子（Krüppel-like factors，KLFs) 是一个具有多个结构高度相似成员的锌指蛋白家族，在真核细胞的基因转录调控过程中起着重要作用。哺乳动物机体中包含这个家族的大部分成员，在人类基因组中至少编码21种Sp1-like/KLF蛋白。KLF4是目前研究较多的一个KLF家族成员，它能够通过与下游基因启动子区的KLF4结合元件相结合，从而直接调控下游基因的转录，是生物体内一种重要的转录因子。研究发现，KLF4在细胞增殖和分化、肿瘤发生和血管重构等生理、病理过程中均起到重要作用。本文就Sp1-like/KLF蛋白家族结构，KLF4的结构特性及其生物学功能进行综述。
Sp1-like proteins and Krüppel-like factors belong to the zinc-finger protein family with multiple members and similar structures, which play the important role in the gene transcriptional regulation of eukaryote cells. For homo sapiens, there are at least 21 kinds of Sp1-like/KLF proteins. KLF4 is a highlight of KLF family members. It can bind with the KLF4 binding element on promoters of target genes to control the transcription of target genes, which is an important transcriptional factor. It has been demonstrated that KLF4 plays the important roles in various physiological and pathological processes, including cell proliferation and differentiation, tumorogenesis and vascular reconstruction. This paper reviews the structure of Sp1-like/KLF protein family, the structural properties of KLF4 and the biological functions of KLF4.
刘瑛、刘俊文
分子生物学细胞生物学
病理学与病理生理学锌指转录因子基因调控Krüppe样因子4KLF4
Pathology and physiopathologyzinc-finger transcriptional factorgene regulationKrüppel-like factor 4KLF4
刘瑛,刘俊文.KLF4蛋白结构与功能[EB/OL].(2013-02-01)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201302-13.点此复制
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