氮杂卡宾催化的开环反应研究进展

Over the past several decades, N-heterocyclic carbene (NHCs) have been used as novel organocatalysts in the development of various organic transformations other than as a traditional source of metal ligands. NHCs have some distinct advantages like easier accessibility and lower toxicity over the traditional metal catalysts, which have drawn much attention and interest. As an important subtype, NHC-catalyzed ring-opening reactions have offered access to a variety of useful products. This review primarily concentrates on the recent advance of NHC-catalyzed ring-opening reactions, including ring-opening of three-, four-, five-, and six-membered rings.