复合微球的聚乳酸静电纺丝纤维作为药物载体的研究

Electrospinning PLLA fiber as a drug carrier has been extensively studied, however, it has a low load efficiency for some water-soluble drug molecules. In this paper, microspheres loaded with water-soluble BSA were prepared by spray drying, and then microspheres were dispersed in PLLA solution. The PLLA microfiber composited drug-loaded microsphere was prepared through the electrospinning technique. The morphology of the composite fiber was studied, and the drug release performance was regulated by adding polyvinylpyrrolidone (PVP). The results showed that the distribution of drug-loaded microspheres in ultra-fine fibers of polylactic acid was uniformity. The release in vitro showed that it has a good drug release properties, and the addition of PVP can significantly speed up its release.