成体平滑肌祖细胞与血管机械损伤修复的研究进展

Smooth muscle progenitor cells, with some smooth muscle markers and stem cell markers, are able to differentiate into smooth muscle cells in vitro directly, and can be induced to differentiate into other cells. Smooth muscle progenitor cells are in various tissues, including bone marrow, blood vessels, peripheral blood, skeletal muscle, kidney and other adult tissues, participation in vascular disease, atherosclerosis, Restenosis, mechanical damage repaired. Generally considered, smooth muscle progenitor cells can differentiate and mitosis to produce a large number of smooth muscle cell, contributed to restenosis when vascular injury. Smooth muscle progenitor cells can secrete a variety of cytokines and growth factors to stabilize the plaque. Recent studies have shown that smooth muscle progenitor cells are an important role in postoperative mechanical damage repair of vascular disease. Different sources of smooth muscle progenitor cells in vascular repair process, after different ways and varying degrees of mechanical damage, are in the role differently. In this paper, research progress, about smooth muscle progenitor cell origin and distribution, the role in vascular mechanical damage repair, was reviewed.