板栗壳斗总酚降血糖和调血脂作用研究

Substantial evidence suggests that phenolic extracts of Castanea mollissima Spiny burs（CMPE）increase pancreatic cell viability after STZ (streptozotocin) treatment as a result of their antioxidant properties. In the present study, the hypoglycemic and hypolipidemic activities of CMPE were studied in normal and STZ-induced diabetic rats. CMPE were orally administrated at dose of 150 and 300 mg/kg twice a day for 12 consecutive days. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels, malondialdehyde (MDA) level and SOD activity in liver, kidney, spleen and heart tissues were spectrophotometrically measured. In normal rats, no significant changes were observed in serum glucose, lipid profiles and tissue MDA and GSH levels after orally administration of CMPE. In diabetic rats, orally administration of CMPE at dose of 300 mg/kg caused significant decrease in serum glucose, triglyceride, total cholesterol, LDL-cholesterol levels, as well as MDA and GSH levels in spleen and liver tissues. However, dosage of 300 mg/kg caused a significant body weight lose in both normal and diabetic rats. The observed effects indicated that CMPE could be further developed as potential compounds to prevent abnormal changes in blood glucose and lipid profile and to attenuate lipid peroxidation in liver and spleen tissues.