Genetics of brain age suggest an overlap with common brain disorders

作者：for the Pediatric Imaging, Neurocognition and Genetics Study、for the AddNeuroMed consortium、Karolinska Schizophrenia Project (KaSP)、Kolsk?r Knut-Kristian、Le Hellard Stephanie、Lundervold Arvid、Maglanoc Luigi A.、Mecocci Patrizia、Nordvik Jan Egil、Papalino Marco、Papassotiropoulos Andreas、Pergola Giulio、Doan Nhat Trung、Agartz Ingrid、Buitelaar Jan、Celius Elisabeth G.、C¨?rdova-Palomera Aldo、Dale Anders M.、Djurovic Srdjan、D?rum Erlend S.、Elvs?shagen Torbj?rn、Fatouros-Bergman Helena、Flyckt Lena、Hartman Catharina A.、Heslenfeld Dirk、H?gest?l Einar A.、Baur-Streubel Ramona、Rokicki Jaroslav、Selb?k Geir、Soininen Hilkka、Vellas Bruno、Westman Eric、Sowa Piotr、Tsolaki Magda、Sanders Anne-Marthe、Persson Karin、Shadrin Alexey A.、Meyer-Lindenberg Andreas、Bertolino Alessandro、Smeland Olav B.、Westlye Lars T.、Bettella Francesco、Borgwardt Stefan、Zink Mathias、Di Carlo Pasquale、Ulrichsen Kristine M.、Moberget Torgeir、H?berg Asta K.、Lund Martina J.、van der Meer Dennis、Wang Lei、Ziegler Georg C.、Eisenacher Sarah、Lundervold Astri J.、J?nsson Erik G.、Richard Genevi¨¨ve、Kaufmann Tobias、de Quervain Dominique J.-F、Harbo Hanne F.、Conzelmann Annette、Jernigan Terry、Schwarz Emanuel、Beyer Mona K.、Franke Barbara、Frei Oleksandr、Aln?s Dag、for the Alzheimer?ˉs Disease Neuroimaging Initiative、Espeseth Thomas、Barch Deanna M.、B?en Erlend、Malt Ulrik F.、Nyberg Lars、Melle Ingrid、Pauli Paul、Norbom Linn B.、Lovestone Simon、Brandt Christine L.、Kirsch Peter、Jonassen Rune、Oosterlaan Jaap、Lesch Klaus-Peter、Landr? Nils Inge、Haatveit Beathe、Cervenka Simon、Hoekstra Pieter J.、Andreassen Ole A.、Steen Vidar M.、K?oszewska Iwona

作者单位：Data used in preparation of this article were obtained from the Pediatric Imaging, Neurocognition and Genetics Study (PING) database ( http://ping.chd.ucsd.edu ). As such, the investigators within PING contributed to the design and implementation of PING and/or provided data but did not participate in analysis or writing of this report. A complete listing of PING investigators can be found at https://ping-dataportal.ucsd.edu/sharing/Authors10222012.pdfAddNeuroMed consortium was led by Simon Lovestone, Bruno Vellas, Patrizia Mecocci, Magda Tsolaki, Iwona K?oszewska, Hilkka SoininenMembers of Karolinska Schizophrenia Project (KaSP)NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of Oslo||Sunnaas Rehabilitation Hospital HTNORMENT, K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of BergenDepartment of Biomedicine, University of Bergen||Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University HospitalNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of OsloInstitute of Gerontology and Geriatrics, University of PerugiaSunnaas Rehabilitation Hospital HTDepartment of Basic Medical Science, Neuroscience, and Sense Organs, University of BariDivision of Molecular Neuroscience, University of Basel||Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel||Life Sciences Training Facility, Department Biozentrum, University of BaselDepartment of Basic Medical Science, Neuroscience, and Sense Organs, University of BariNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychiatry, Diakonhjemmet Hospital||Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County CouncilDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center||Karakter Child and Adolescent Psychiatry University CentreInstitute of Health and Society, University of Oslo||Department of Neurology, Oslo University HospitalNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Pediatrics, Stanford University School of Medicine, Stanford UniversityDepartment of Radiology, University of California Department of Neurosciences, University of CaliforniaDepartment of Medical Genetics, Oslo University Hospital||NORMENT, K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of BergenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of Oslo||Sunnaas Rehabilitation Hospital HTNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Institute of Clinical Medicine, University of Oslo||Department of Neurology, Oslo University HospitalDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County CouncilDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County CouncilDepartment of Psychiatry, University of Groningen, University Medical Center GroningenDepartment of Clinical Neuropsychology, Vrije Universiteit Amsterdam||Department of Cognitive Psychology, Vrije Universiteit AmsterdamInstitute of Clinical Medicine, University of Oslo||Department of Neurology, Oslo University HospitalDepartment of Psychology I, University of W¨1rzburgNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of OsloNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust||Centre for Old Age Psychiatric Research, Innlandet Hospital Trust||Institute of Health and Society, University of OsloDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland||Neurocenter, Neurology, Kuopio University HospitalINSERM U 1027, University of ToulouseDepartment of Neurobiology, Care Sciences and Society, Karolinska Institute||Institute of Psychiatry, King?ˉs CollegeDepartment of Radiology and Nuclear Medicine, Section of Neuroradiology, Oslo University HospitalDepartment of Neurology, Aristotle University of ThessalonikiNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of Oslo||Sunnaas Rehabilitation Hospital HTDepartment of Geriatric Medicine, Oslo University Hospital||Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital TrustNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg UniversityInstitute of Psychiatry, Bari University Hospital||Department of Basic Medical Science, Neuroscience, and Sense Organs, University of BariNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of OsloNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloDepartment of Psychiatry (UPK), University of Basel||Institute of Psychiatry, King?ˉs CollegeDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University||District hospital AnsbachDepartment of Basic Medical Science, Neuroscience, and Sense Organs, University of BariNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of Oslo||Sunnaas Rehabilitation Hospital HTNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology||Department of Radiology and Nuclear Medicine, St. Olavs HospitalNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloFeinberg School of Medicine, Northwestern UniversityDivision of Molecular Psychiatry, Center of Mental Health, University of W¨1rzburgDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Biological and Medical Psychology, University of Bergen||K. G. Jebsen Centre for Neuropsychiatric Disorders, University of BergenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County CouncilNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of Oslo||Sunnaas Rehabilitation Hospital HTNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloDivision of Cognitive Neuroscience, University of Basel||Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of BaselDepartment of Neurology, Oslo University Hospital||Institute of Clinical Medicine, University of OsloChildren and Adolescence Psychiatry, University of T¨1bingenCenter for Human Development, University of California||Department of Cognitive Science, University of California||Departments of Psychiatry and Radiology, University of CaliforniaDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg UniversityInstitute of Clinical Medicine, University of Oslo||Department of Radiology and Nuclear Medicine, Section of Neuroradiology, Oslo University HospitalDepartments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical CenterNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloData used in preparation of this article were obtained from the Alzheimer?ˉs Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf .Department of Psychology, University of OsloDepartment of Psychological and Brain Sciences, Washington University in St. Louis||Department of Psychiatry, Washington University in St. Louis||Department of Radiology, Washington University in St. LouisDepartment of Psychiatry, Diakonhjemmet HospitalInstitute of Clinical Medicine, University of Oslo||Department of Research and Education, Oslo University HospitalDepartment of Radiation Science, Ume? UniversityNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloDepartment of Psychology I, University of W¨1rzburgNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of OsloDepartment of Psychiatry, Warneford Hospital, University of OxfordNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloDepartment of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University||Bernstein Center for Computational Neuroscience Heidelberg/MannheimDepartment of Psychology, University of OsloDepartment of Clinical Neuropsychology, Vrije Universiteit Amsterdam||Emma Children?ˉs Hospital Amsterdam Medical Center||VU University Medical Center, Department of PediatricsDivision of Molecular Psychiatry, Center of Mental Health, University of W¨1rzburg||Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University||Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht UniversityDepartment of Psychology, University of Oslo||Department of Psychiatry, Diakonhjemmet HospitalNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo||Department of Psychology, University of OsloDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County CouncilDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of GroningenNORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of OsloNORMENT, K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen||Dr. E. Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University HospitalDepartment of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz

DOI：10.1101/303164

学科分类：神经病学、精神病学遗传学基础医学

英文关键词：Brain age gapbrain disordersgenetic architecturepleiotropy

推荐引用：for the Pediatric Imaging, Neurocognition and Genetics Study,for the AddNeuroMed consortium,Karolinska Schizophrenia Project (KaSP),Kolsk?r Knut-Kristian,Le Hellard Stephanie,Lundervold Arvid,Maglanoc Luigi A.,Mecocci Patrizia,Nordvik Jan Egil,Papalino Marco,Papassotiropoulos Andreas,Pergola Giulio,Doan Nhat Trung,Agartz Ingrid,Buitelaar Jan,Celius Elisabeth G.,C¨?rdova-Palomera Aldo,Dale Anders M.,Djurovic Srdjan,D?rum Erlend S.,Elvs?shagen Torbj?rn,Fatouros-Bergman Helena,Flyckt Lena,Hartman Catharina A.,Heslenfeld Dirk,H?gest?l Einar A.,Baur-Streubel Ramona,Rokicki Jaroslav,Selb?k Geir,Soininen Hilkka,Vellas Bruno,Westman Eric,Sowa Piotr,Tsolaki Magda,Sanders Anne-Marthe,Persson Karin,Shadrin Alexey A.,Meyer-Lindenberg Andreas,Bertolino Alessandro,Smeland Olav B.,Westlye Lars T.,Bettella Francesco,Borgwardt Stefan,Zink Mathias,Di Carlo Pasquale,Ulrichsen Kristine M.,Moberget Torgeir,H?berg Asta K.,Lund Martina J.,van der Meer Dennis,Wang Lei,Ziegler Georg C.,Eisenacher Sarah,Lundervold Astri J.,J?nsson Erik G.,Richard Genevi¨¨ve,Kaufmann Tobias,de Quervain Dominique J.-F,Harbo Hanne F.,Conzelmann Annette,Jernigan Terry,Schwarz Emanuel,Beyer Mona K.,Franke Barbara,Frei Oleksandr,Aln?s Dag,for the Alzheimer?ˉs Disease Neuroimaging Initiative,Espeseth Thomas,Barch Deanna M.,B?en Erlend,Malt Ulrik F.,Nyberg Lars,Melle Ingrid,Pauli Paul,Norbom Linn B.,Lovestone Simon,Brandt Christine L.,Kirsch Peter,Jonassen Rune,Oosterlaan Jaap,Lesch Klaus-Peter,Landr? Nils Inge,Haatveit Beathe,Cervenka Simon,Hoekstra Pieter J.,Andreassen Ole A.,Steen Vidar M.,K?oszewska Iwona.Genetics of brain age suggest an overlap with common brain disorders[EB/OL].(2025-03-28)[2025-04-24].https://www.biorxiv.org/content/10.1101/303164.点此复制