芳基炔丙醇的串联环化反应合成6,9-二氢吡啶并[1,2-a]吲哚

strategy for the synthesis of 6,9-dihydropyrido[1,2-a]indoles through a cascade iodocyclization of 4-(3-methyl-1H-indol-1-yl)-1,1-diphenylbut-2-yn-1-ol derivatives is presented. This reaction is concisely conducted under very mild condition and in a short time. Both of the iodine cation and anion generated from I2 are used effectively, The reactions are environmental friendly, avoiding the use of precious metals and toxic metals, obtaining a series of diiodinated 6,9-dihydropyrido[1,2-a]indoles with good yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds.