Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries
Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries
Abstract BackgroundPreviously reported associations of protein-rich foods with stroke subtypes have prompted interest in assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study. MethodsWe analysed data on 356,142 participants from seven European countries. Dietary intakes of 19 individual amino acids were assessed using validated country-specific dietary questionnaires, calibrated using additional 24-hour dietary recalls. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of ischaemic and haemorrhagic stroke in relation to intake of each amino acid. The role of blood pressure as a potential mechanism was assessed in 267,642 (75%) participants. ResultsAfter a median follow-up of 12.9 years, 4,295 participants had an ischaemic stroke and 1,375 participants had a haemorrhagic stroke. After correction for multiple testing, higher intake of proline (as percent of total protein) was associated with 12% lower risk of ischaemic stroke (HR per 1 SD higher intake 0.88; 95% CI 0.82, 0.94). The association persisted after mutual adjustment for all other amino acids, systolic and diastolic blood pressure. The inverse associations of isoleucine, leucine, valine, phenylalanine, threonine, tryptophan, glutamic acid, serine and tyrosine with ischaemic stroke were each attenuated with adjustment for proline intake. For haemorrhagic stroke, no statistically significant associations were observed in the continuous analyses after correcting for multiple testing. ConclusionHigher proline intake was associated with a lower risk of ischaemic stroke, independent of other dietary amino acids and blood pressure.
Schiborn Catarina、Tong Tammy Y.N.、Travis Ruth C.、Sieri Sabina、de Magistris Maria Santucci、Boer Jolanda M.A.、Petrova Dafina、Engstr?m Gunnar、Johansson Kristina、Aglago Elom K.、Key Timothy J.、Overvad Kim、Tj?nneland Anne、Schulze Matthias B.、Danesh John、Amiano Pilar、Masala Giovanna、Mayen-Chacon Ana-Lucia、Katzke Verena、Butterworth Adam S.、Dahm Christina C.、Aleksandrova Krasimira、Crous-Bou Marta、Imamura Fumiaki、Verschuren W.M. Monique、Kyr? Cecilie、Huybrechts Inge、Kaaks Rudolf、van der Schouw Yvonne T.、Forouhi Nita G.、Brustad Magritt、Huerta Jos¨| Mar¨aa、Heath Alicia K.、Weiderpass Elisabete、Tumino Rosario、N?st Therese Haugdahl、Moreno-Iribas Conchi、Sacerdote Carlotta、Melander Olle、Lindvall Kristina、Schmidt Julie A.、Noor Urwah、Clarke Robert
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke||German Center for Diabetes Research (DZD)Nuffield Department of Population Health, University of OxfordNuffield Department of Population Health, University of OxfordEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di MilanoAzienda Ospedaliera Universitaria Federico IINational Institute for Public Health and the EnvironmentEscuela Andaluza de Salud P¨2blica (EASP)||Instituto de Investigaci¨?n Biosanitaria ibs.GRANADA||Instituto de Salud Carlos IIIDepartment of Clinical Science in Malm?, Lund University, Clinical Research CenterDepartment of Public Health and Clinical medicine, Ume? UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonNuffield Department of Population Health, University of OxfordDepartment of Public Health, Aarhus UniversityDanish Cancer Society Research CenterDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke||Institute for Nutritional Science, University of PotsdamBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge||National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge||British Heart Foundation Centre of Research Excellence, University of Cambridge||Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge||Department of Human Genetics, Wellcome Sanger InstituteInstituto de Salud Carlos III||Ministry of Health of the Basque Government||Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases GroupInstitute for cancer research, prevention and clinical network (ISPRO)Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge||National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge||British Heart Foundation Centre of Research Excellence, University of Cambridge||Health Data Research UK Cambridge, Wellcome Genome Campus and University of CambridgeDepartment of Public Health, Aarhus UniversityDepartment Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS||Faculty of Human and Health Sciences, University of BremenUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL). L?ˉHospitalet de Llobregat||Department of Epidemiology, Harvard T.H. Chan School of Public Health. BostonUniversity of Cambridge School of Clinical MedicineJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University||National Institute for Public Health and the EnvironmentDanish Cancer Society Research CenterNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC)Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityUniversity of Cambridge School of Clinical MedicineDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway||The Public Dental Service Competence Centre of Northern Norway (TkNN)Instituto de Salud Carlos III||Department of EpidemiologyDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonInternational Agency for Research on Cancer (IARC)Hyblean Association for Epidemiological Research AIRE-ONLUSDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway||K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and TechnologyInstituto de Salud Carlos III||Navarra Institute for Health Research (IdiSNA) SpainInstituto de Salud P¨2blica de Navarra Navarre Institute for Health ResearchUnit of Cancer Epidemiology, Citt¨¤ della Salute e della Scienza University-HospitalDepartment of Clinical Science in Malm?, Lund University, Clinical Research Center||Department of Emergency and Internal Medicine, Sk?ne University HospitalDepartment of Epidemiology and Global Health, Ume? UniversityNuffield Department of Population Health, University of Oxford||Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital and Aarhus UniversityNuffield Department of Population Health, University of OxfordClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health
医药卫生理论医学研究方法预防医学
amino acidsdietary proteinischaemic strokehaemorrhagic strokenutritional epidemiologyprospective cohort
Schiborn Catarina,Tong Tammy Y.N.,Travis Ruth C.,Sieri Sabina,de Magistris Maria Santucci,Boer Jolanda M.A.,Petrova Dafina,Engstr?m Gunnar,Johansson Kristina,Aglago Elom K.,Key Timothy J.,Overvad Kim,Tj?nneland Anne,Schulze Matthias B.,Danesh John,Amiano Pilar,Masala Giovanna,Mayen-Chacon Ana-Lucia,Katzke Verena,Butterworth Adam S.,Dahm Christina C.,Aleksandrova Krasimira,Crous-Bou Marta,Imamura Fumiaki,Verschuren W.M. Monique,Kyr? Cecilie,Huybrechts Inge,Kaaks Rudolf,van der Schouw Yvonne T.,Forouhi Nita G.,Brustad Magritt,Huerta Jos¨| Mar¨aa,Heath Alicia K.,Weiderpass Elisabete,Tumino Rosario,N?st Therese Haugdahl,Moreno-Iribas Conchi,Sacerdote Carlotta,Melander Olle,Lindvall Kristina,Schmidt Julie A.,Noor Urwah,Clarke Robert.Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries[EB/OL].(2025-03-28)[2025-06-30].https://www.medrxiv.org/content/10.1101/2023.08.15.23294122.点此复制
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