二尖瓣病变患者血浆赖氨酸氧化酶水平与心房颤动的关系

Objective Our early study showed atrial fibrosis has relationship with occurrence and maintain of AF, Lysyl Oxidase(LOX) is a key enzyme control fibrosis cross-linking, so we investigate whether LOX have significant relation to persistent atrial fibrillation (AF) with mitral valvular diseases. Methods We studied 184 consecutive lone mitral valvular disease patients who need surgery. At baseline, all patients underwent a physical examination, 12-lead electrocardiography and echocardiography. Patients who had persistent AF formed the AF group, and those who still kept sinus rhythm (SR) comprised the SR group. In AF group, patients were separated into two groups by the subgroup of mitral valvular disease (mitral stenosis and mitral regurgitation), then formed MS+AF group and MR+AF group. Blood specimens were obtained from patients for the first time peripheral venous blood after admitted to hospital. LOX levels were measured by ELISA test kits of LOX. Results AF was diagnosed in 51.87% (97/187of lone mitral valvular disease patients. Mitral stenosis patients were easy to have AF (60.31% vs. 34.43%, p <0.05). The plasma level of LOX was significantly higher in AF group than in SR group (72.60 ±22.03 vs. 56.40±17.96，p<0.05). In AF group, the LOX level in mitral stenosis group was higher than in mitral regurgitation group (73.78±25.42 vs. 51.05±18.96，p<0.05). Mitral stenosis patients more frequently had a history of stroke than mitral regurgitation patients. AF correlated significantly with the level of LOX (r=0.124，p=0.036) and left atrial dimension (r=0.531，p=0.042). Conclusions We validated and extended the hypothesis that increasing LOX level predicted an increasing risk of AF in mitral valvular diseases. Lysine oxidase is a potential diagnostic biomarker for AF. It was expressed significantly in mitral stenosis patients with AF especially.