多孔壳聚糖微球的制备及其性能研究
Preparation of porous chitosan microspheres and studies on its properties
采用交联法制备了聚乙二醇改性壳聚糖微球，利用甲苯作为有机分散介质，戊二醛作为交联剂，聚乙二醇为致孔剂，通过反相悬液交联法制备了微米级窄分布多孔壳聚糖微球。并将其用于研究聚乙二醇分子量对所成球粒径的影响。结果表明：在pH为10-11、搅拌速度为120r/min、戊二醛的滴定速度为0.26mL/min时最有利于成球。
Porous chitosan microspheres, a kind of carrier, was applied to discuss the molecular weight of polyethylene glycol into the impact of the ball diameter. Chitosan was modified with toluene as dispersed medium , PEG as porogen and glutaraldehyde as cross-linking agent and modified by polyethylene glycol. And narrow-distribution of the micro-porous chitosan microspheres was prepared by RP-suspension cross-linking. The optimum conditions for preparing porous chitosan microspheres were as follows: the pH was between 10 to 11, stirring speed was 120r/min, and the titration rate of glutaraldehyde was 0.26mL/min.
张丽、王刚、周夫涛
生物工程学材料科学
反相悬液交联法壳聚糖多孔性能
RP-suspension cross-linkinghitosanporousproperties
张丽,王刚,周夫涛.多孔壳聚糖微球的制备及其性能研究[EB/OL].(2010-05-27)[2025-08-19].http://www.paper.edu.cn/releasepaper/content/201005-738.点此复制
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