弱阳离子交换整体柱作为固相萃取材料测定血液中的氟桂利嗪

monolithic column affording cationic functionalities was prepared and modified on-line by ethylenediamine and monochloracetic acid respectively. The column was used for analysis and determination of flunarizine in plasma. The on–line sample deproteinization was carried out , and the enrichment of drugs had been completed at the same time. The properties of the column were investigated and the column exhibited good stability, recovery and precision. The method avoided tedious pretreatment and provided a very simple, cheap, effective method for assaying drugs in the blood. After regeneration, the monolithic column could be used repetitiously and no obvious changes in column efficiency and back pressure were observed within two months.