caveolin1缺失对局灶性脑缺血小鼠神经功能及脑梗死面积的影响
Effect of caveolin1 on nerve function and infarct volume in mice after focal cerebral ischemia
目的：评价caveolin1对局灶性脑缺血损伤中的作用。方法：分别对 caveolin1基因敲除小鼠和同源野生C57小鼠行MCAO术造成脑缺血损伤模型。于术后1d、7d进行TTC染色、大脑干湿质量比，评价梗死体积比脑水肿程度，并进行神经功能评分。结果：与野生型小鼠比较，caveolin1基因缺失加重MCAO脑损伤，减缓其神经功能恢复，加重脑水肿。结论：caveolin-1在MCAO早期可能具有抗脑损伤和脑保护作用。
Objective：To evaluate the role of caveolin1 in mice after focal cerebral schemia．Methods：Mice(CAV1+/+ AND CAV1-/-) were reproduced by middle cerebral artery occlusion, Neurological functional score were evaluated after surgery before the execution, 5 rats were randomly taken from each group and calculated infarct size ratio by TTC, others were calculat the ratio of wet and dry brain. Results：Compared with wild-type mice，CAV1 deletion can significant delays restoration of neurological deficits and infarct size and abate the brain edema in mice．Conclusion：Caveolin1 may play a protective role in mice after focal cerebral ischemia．
刘柏炎、易健、蔡光先、陈雪梅、俞悦
神经病学、精神病学基础医学
小窝蛋白基因敲除小鼠局灶性脑缺血神经功能评分梗死面积比大脑干湿重比
aveolin 1kncok-out mousecerebral ischemiaNeurological function scoreinfarct size ratioThe ratio of wet and dry brain
刘柏炎,易健,蔡光先,陈雪梅,俞悦.caveolin1缺失对局灶性脑缺血小鼠神经功能及脑梗死面积的影响[EB/OL].(2011-10-28)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201110-309.点此复制
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