Carriage of antimicrobial-resistant Enterobacterales among pregnant women and newborns in Amhara, Ethiopia
Carriage of antimicrobial-resistant Enterobacterales among pregnant women and newborns in Amhara, Ethiopia
Abstract BackgroundInfections are one of the most common causes of neonatal mortality, and maternal colonization has been associated with neonatal infection. Data on carriage of bacterial pathogens and mother-child transmission patterns in low- and middle-income countries is sparse. MethodsWe sought to quantify carriage prevalence of extended-spectrum-beta-lactamase (ESBL) - producing and carbapenem-resistant Enterobacterales (CRE) among pregnant women and their neonates and to characterize risk factors for carriage in a rural area of Amhara, Ethiopia. We sampled 211 pregnant women in their third trimester and/or labor/delivery and 159 of their neonates in the first week of life. ResultsWe found that carriage of ESBL-producing organisms was fairly common (women: 22.3%, 95% CI: 16.8-28.5; neonates: 24.5%, 95% CI: 18.1-32.0), while carriage of CRE (women: 0.9%, 95% CI: 0.1-3.4; neonates: 2.5%, 95% CI: 0.7-6.3) was rare. Neonates whose mothers tested positive for ESBL-producing organisms were nearly twice as likely to also test positive for ESBL-producing organisms (38.7% vs. 21.1%, p-value: 0.06). Carriage of ESBL-producing organisms was also associated with woreda (district) of sample collection (Fisher exact test maternal p-value: <0.01; neonatal p-value: <0.01) and recent antibiotic use (maternal p-value: 0.55; neonatal p-value: 0.011). ConclusionsUnderstanding carriage patterns of potential pathogens and antibiotic susceptibility among pregnant women and newborns in this region will help to inform local, data-driven recommendations to prevent and treat neonatal infections. Main pointCarriage prevalence of ESBL-producing Enterobacterales was high among pregnant women and neonates in a rural area of Ethiopia, and neonates were more likely to test positive if their mother tested positive. This work informs prevention and treatment of neonatal infections.
Bekele Delayehu、Chan Grace、Hunegnaw Bezawit M.、Smith Marshagne、Perovic Olga、Taddesse Lisanu、Gebru Addisalem、Amsalu Getnet、Tadesse Fisseha、Fikre Addisalem、Wen Christine Tedijanto
St. Paul?ˉs Hospital Millennium Medical College||HaSET Maternal and Child Health Research Program||Department of Obstetrics and Gynecology, St. Paul?ˉs Hospital Millennium Medical College||Department of Epidemiology, Harvard T.H. Chan School of Public HealthSt. Paul?ˉs Hospital Millennium Medical College||HaSET Maternal and Child Health Research Program||Division of Medical Critical Care, Boston Children?ˉs Hospital, Harvard Medical School||Department of Epidemiology, Harvard T.H. Chan School of Public HealthSt. Paul?ˉs Hospital Millennium Medical College||HaSET Maternal and Child Health Research Program||Department of Pediatrics and Child Health, St. Paul?ˉs Hospital Millennium Medical CollegeUniversity of Witwatersrand, Department of Clinical Microbiology and Infectious DiseasesThe National Institute for Communicable Diseases, a division of NHLS||University of Witwatersrand, Department of Clinical Microbiology and Infectious DiseasesHaSET Maternal and Child Health Research ProgramHaSET Maternal and Child Health Research Program||Debre Birhan HospitalSt. Paul?ˉs Hospital Millennium Medical College||HaSET Maternal and Child Health Research ProgramDebre Birhan HospitalSt. Paul?ˉs Hospital Millennium Medical College||HaSET Maternal and Child Health Research ProgramSurgo Health, District of Columbia
医学研究方法预防医学妇产科学
antibiotic resistanceESBLCREneonatespregnancysepsisvertical transmission
Bekele Delayehu,Chan Grace,Hunegnaw Bezawit M.,Smith Marshagne,Perovic Olga,Taddesse Lisanu,Gebru Addisalem,Amsalu Getnet,Tadesse Fisseha,Fikre Addisalem,Wen Christine Tedijanto.Carriage of antimicrobial-resistant Enterobacterales among pregnant women and newborns in Amhara, Ethiopia[EB/OL].(2025-03-28)[2025-05-28].https://www.medrxiv.org/content/10.1101/2023.05.29.23290490.点此复制
评论