叶酸合成工艺的优化

Folic acid is a pteroic acid mono glutamate. It is one of the vitamin B complex. The existing process for the manufacture of folic acid has the disadvantage of generating large amount waste water causing serious environmental pollution. Therefore, the development of green process for the production of folic acid is necessary. In this paper we optimized the traditional production process of folic acid. The reaction of L-N-aminobenzoyl glutamic acid, 2,4,5-triamino-6-hydroxypyrimidine sulfate and 1,1,3-trichloroacetone was run in 50% aqueous solution of ethanol instead of pure water to synthesize folic acid, which reduced the water consumposition of 93%. It was found that the crystalline 1,1,3-thichloro-acetone can be obtained from the recrystalization of crude 1,1,3-thichloro-acetone from petroleum ether-water mixture. The yield of folic acid was increased about 10% by using crystalline 1,1,3-thichloro-acetone as raw material.