氮杂卡宾催化的氢酰化反应研究进展

Over the last decade, N-heterocylic carbenes (NHCs) have been utilized as novel organocatalysts in the development of various organic reactions other than a traditional source of metal ligands. As an important subtype, NHC-catalyzed hydroacylation usually employs aldehydes as the acyl donor, which react with different acyl acceptors such as C-C double bonds, C-C triple bonds and C-O double bonds and afford reductive acyl products. NHCs have some distinct advantages like easier accessiblity and lower toxicity over the traditional metal catalysts, which make it become a new field of study of increasing interest. This review mainly focuses on the recent advance of N-heterocyclic carbene-catalyzed hydroacylation, involving the reactions of alkenes, alkynes and carbonyls.