Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2
Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2
Abstract Characterization of the humoral response to SARS-CoV-2, the etiological agent of Covid-19, is essential to help control the infection. In this regard, we and others recently reported that the neutralization activity of plasma from COVID-19 patients decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we selected plasma from a cohort of Covid-19 convalescent patients and selectively depleted immunoglobulin A, M or G before testing the remaining neutralizing capacity of the depleted plasma. We found that depletion of immunoglobulin M was associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of IgM.
Finzi Andr¨|s、Pr¨|vost J¨|r¨|mie、Fink Corby、Ducas ¨|ric、Landry Patricia、Tremblay Tony、Beaudoin-Bussi¨¨res Guillaume、Laumaea Annemarie、Medjahed Halima、Gasser Romain、Bazin Ren¨|e、Cloutier Marc、Richard Jonathan、Dikeakos Jimmy D.、Dekaban Gregory A.、Larochelle Catherine、Lewin Antoine、Laforce-Lavoie Audrey、Ding Shilei、Dussault Nathalie
Centre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|al||Department of Microbiology and Immunology, McGill UniversityCentre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alBiotherapeutics Research Laboratory, Robarts Research Institute||Department of Microbiology and Immunology, University of Western OntarioH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationCentre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alCentre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alCentre de recherche du CHUMCentre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationCentre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alDepartment of Microbiology and Immunology, University of Western OntarioBiotherapeutics Research Laboratory, Robarts Research Institute||Department of Microbiology and Immunology, University of Western OntarioCentre de recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|al||Department of Neurosciences, University of MontrealH¨|ma-Qu¨|bec, Affaires M¨|dicales et Innovation||Facult¨| de m¨|decine et des sciences de la sant¨|, Universit¨| de SherbrookeH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationCentre de recherche du CHUMH¨|ma-Qu¨|bec, Affaires M¨|dicales et Innovation
医药卫生理论医学研究方法基础医学
COVID-19SARS-CoV-2Spike glycoproteinIgMIgAIgGneutralizationconvalescent plasma
Finzi Andr¨|s,Pr¨|vost J¨|r¨|mie,Fink Corby,Ducas ¨|ric,Landry Patricia,Tremblay Tony,Beaudoin-Bussi¨¨res Guillaume,Laumaea Annemarie,Medjahed Halima,Gasser Romain,Bazin Ren¨|e,Cloutier Marc,Richard Jonathan,Dikeakos Jimmy D.,Dekaban Gregory A.,Larochelle Catherine,Lewin Antoine,Laforce-Lavoie Audrey,Ding Shilei,Dussault Nathalie.Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.10.09.333278.点此复制
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