芹菜素诱导乳头状甲状腺癌细胞自噬的研究

pigenin, a natural edible plant flavone which abundantly occurs in many fruits and vegetables, is recognized as a flavonoid with anti-inflammatory, antioxidant and anticancer properties. In this study, we investigated the effects of apigenin on the level of autopahgy in papillary thyroid carcinomas (PTC) cell line BCPAP. The results show that apigenin inhibited, in a dose dependent manner, BCPAP cell proliferation, with strong inhibition occurring at 50μM; and induced autophagy level as shown by the expression of several molecular markers such as LC3, p62, and Beclin 1. Furthermore, AO staining were performed to probe the formation of autophagic vacuole in apigenin-treated BCPAP cells. In summary, our results demonstrate that apigenin inhibits viability of BCPAP cells and simultaneously stimulates autophagy.