转录激活因子3及其在肿瘤中的研究进展

ctivating Transcription Factor 3 (ATF3) is a leucine zipper-containing protein that belongs to the activating transcription factor/cAMP responsive element binding protein (ATF/CREB) family. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers. Finally, our recent studies in esophageal cancer revealed that ATF3 might be a tumor suppressor.