聚乙二醇1000维生素E琥珀酸酯对小鼠胸腺细胞凋亡的影响

his study set up a thymus cell apoptosis model by in vivo injection of dexamethasone (DEX). Observed morphological changes of cell by ordinary microscope and calculated the apoptotic rate, combined with agarose gel electrophoresis. Made a qualitative and quantitative research of the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) on thymus cell apoptosis. The results showed that TPGS inhibited thymus cell apoptosis which induced by DEX and decreased the apoptosis rate. The inhibition was dose-dependent, which means, comparing to the positive control group, 1 time and 5 times dosage were extremely significantly, when it increased to 10 times and 20 times dosage, the inhibiton became insignificant.