乳腺癌组织中BCRP表达与临床病理参数的相关性研究

Objective To discuss the correlation of the expression of BCRP with clinical index and pathological parameters such as ER, PR, HER-2 and P53 in breast cancer. Methods The protein expression of BCRP, ER, PR, HER-2 and P53 were examined using immunohistochemistry. The correlations of BCRP with the clinical data as well as the pathological parameters were analyzed by Kruskal-Wallis nonparametric test and Spearman correlate test. Results the positive expression rate of BCRP in breast cancer was significantly higher than that in the adjacent tissues (64.39% vs. 33.33%, X2=9.323, P=0.002). The expression of BCRP in breast cancer tissues was not associated with histological types, age, clinical stage or lymph node metastases state, but was significantly different between the pre menopause and the post-menopause patients (X2=6.928，P=0.008). The expression of BCRP was positively correlated with the expressions of ERα (r=0.204，P=0.019) or HER-2 (r=0.246，P=0.004) respectively, but no correlation with P53 or PR. Conclusion the protein level of BCRP in breast cancer was higher than that in the adjacent tissues and positively correlated with the estrogen level as well as the expressions of ERα and HER-2.