蓝萼甲素保护新生大鼠缺氧缺血性脑损伤

Objective. To investigate the effect of Glaucocalyxin A in a Rat Neonatal Hypoxic-Ischemic Brain Injury model Methods. New born rats were used to set up the HIBD model. Brain atrophy was assessed at 4 weeks after HI; Morris Water Maze Test has been used to examine exploratory learning and working memory by hippocampus dysfunction; TTC staining was performed to determine the infarct volume. Results. At 4 weeks after HI, extensive atrophy of ipsilateral brain tissue was observed, which means HI influence brain development; the HI group showed a significantly longer escape latency（n=10，p<0.01）and a lower frequency of original platform crossing compared with the sham-operated group（n=10，p<0.01）;in TTC staining , compared with the vehicle group, the infarct volume in the GLA 500μg/kg group and the GLA 1 mg /kg group was significant smaller（n=10，p<0.01）. Conclusion. In this study, we concluded that neonatal hypoxic-ischemic brain Injury influence the development of rat brain and subsequent spatial learning and memory ability. GLA is effective in protecting brain damage from HIBD model.