EGCG降低UVB引发的人视网膜色素上皮细胞损伤初步研究
he preliminary study on the effect of EGCG alleviating the RPE cells injure induced by UVB irradiation
过量的中波紫外线（UVB）辐射是引发人视网膜色素上皮细胞（UVB）损伤的主因。本研究通过建立RPE细胞的UVB损伤模型研究EGCG对RPE细胞的保护作用。通过MTT、细胞活性氧含量分析、激光共聚焦分析，结果表明EGCG可以减少UVB胁迫下的RPE细胞的损伤，避免UVB引起的细胞凋亡增加的现象。
Excessive exposure to ultraviolet B (UVB) is one of the major factors to the injure of human retinal pigment epithelia cells (RPE). In this study, a UVB injury model was established to investigate the protect effect of epigallocatechin gallate (EGCG). The MTT assay and confocal laser microscopy were conduct and the results showed that the EGCG could alleviate the RPE cells injure induced by UVB irradiation, inhibiting the increase of cell apoptosis.
林宏政、金珊、林金科、吴亮宇、王艳娜、郭雅玲
基础医学眼科学生物科学研究方法、生物科学研究技术
茶表没食子儿茶素没食子酸酯中波紫外辐射视网膜色素上皮细胞保护作用
amellia sinensisepigallocatechin gallateultraviolet Bretinal pigment epithelia cellsprotective effect
林宏政,金珊,林金科,吴亮宇,王艳娜,郭雅玲.EGCG降低UVB引发的人视网膜色素上皮细胞损伤初步研究[EB/OL].(2016-05-12)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201605-254.点此复制
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