Met is required for oligodendrocyte progenitor cell migration in Danio rerio
Met is required for oligodendrocyte progenitor cell migration in Danio rerio
Abstract During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo, the role of Met signaling in OPC migration and provide new insight into how OPC migration is regulated during development.
Kucenas Sarah、Wang Yinxue、Latimer Andrew J.、Isabella Adam J.、Yu Guoqiang、Hogenmiller Leah、Fontenas Laura、Ali Maria F.、Moens Cecilia B.
Department of Biology, University of VirginiaDepartment of Electrical and Computer Engineering, Virginia Polytechnic Institute and State UniversityDepartment of Biology, University of VirginiaDivision of Basic Sciences, Fred Hutchinson Cancer Research CenterDepartment of Electrical and Computer Engineering, Virginia Polytechnic Institute and State UniversityDepartment of Biology, University of VirginiaDepartment of Biology, University of VirginiaDepartment of Biology, University of VirginiaDivision of Basic Sciences, Fred Hutchinson Cancer Research Center
分子生物学细胞生物学遗传学
oligodendrocyte progenitor cellsMet receptorglial migrationspinal cord developmentzebrafish
Kucenas Sarah,Wang Yinxue,Latimer Andrew J.,Isabella Adam J.,Yu Guoqiang,Hogenmiller Leah,Fontenas Laura,Ali Maria F.,Moens Cecilia B..Met is required for oligodendrocyte progenitor cell migration in Danio rerio[EB/OL].(2025-03-28)[2025-05-25].https://www.biorxiv.org/content/10.1101/2021.05.21.445204.点此复制
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