慢性低剂量染毒MC-LR对雄性小鼠生殖系统的损伤
he toxic effect of chronic low-dose exposure to MC-LR on male mice reproduction
本实验研究了慢性低剂量染毒微囊藻毒素对雄性小鼠精子质量和睾丸功能的影响。小鼠分别口服MC-LR浓度为0, 1, 3.2, 和 10μg/L 的饮用水3个月和6个月。3个月组结果显示，小鼠精子质量在浓度为3.2 和 10μg/L时有所下降，睾酮在10μg/L时降低，LH和FSH都呈现出上升的趋势，并且间质细胞也有凋亡的现象出现；6个月组结果显示，MC-LR的毒性效应更加明显，与对照组（0 μg/L）相比，在MC-LR浓度为3.2和10μg/L时，精子畸形率显著上升，睾酮水平显著下降，并且睾丸结构在浓度为10μg/L时也出现损伤。因此，慢性低剂量染毒MC-LR对雄性生殖系统有毒性效应，可以导致精子质量的下降，血清中睾酮水平的下降和睾丸结构的损伤。
In this paper the effects of chronic low-dose exposure to microcystins were studied on male mice reproduction. Male mice were treated with microcystin-LR (MC-LR) orally at 0, 1, 3.2, and 10μg/L for 3 and 6 months. Our results showed that in three-month group, sperm quality decreased at 3.2 and 10μg/L doses, testosterone declined at 10μg/L, LH and FSH had a slight increased, and apoptosis was observed in Leydig cells. The similar but more promouced results were observed in six-month group. Compared to control (0 μg/L), testosterone levels dropped at 3.2 and 10μg/L and the rate of sperm abnormality was higher in these two doses of MC-LR. Also, the structural damage to the testis was observed in 10μg/L dose. Thus, chronic low-dose exposure to MC-LR results in toxicity to male reproduction, causing declines in sperm quality, decreased levels of serum testosterone, and damage to the testis.
韩晓冬、陈煜
基础医学环境科学理论环境生物学
Microcystin-LR慢性低剂量雄性生殖系统毒性
Microcystin-LRchronic low dosemale reproductive systemtoxicity
韩晓冬,陈煜.慢性低剂量染毒MC-LR对雄性小鼠生殖系统的损伤[EB/OL].(2012-05-07)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201205-91.点此复制
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