可快速释药的核-壳结构型载药敷料

Purpose: Appropriate drug-loaded dressings could provide a good healing microenvironment for wounds. In order to increase the patient\'s compliance when changing dressing for wound, a multilayer core-shell drug loading dressing was prepared, which could quickly release lidocaine at the site of application. Methods: AMs were prepared by emulsification-ion cross-linking method, and then chitosan@pore gelatin@alginate calcium microspheres (CPAMs) were prepared by template-emulsification gel method, and CPAMs were characterized and the lidocaine release and coagulation properties in vitro were investigated. Results: The experimental results showA core-shell structure drug - loading dressing with rapid drug releaseed that CPAMS was a lidocaine dressing with cores-shellA core-shell structure drug - carrying dressing with rapid drug release structure constructed from chitosan, porous gelatin and calcium alginate. CPAMs allowed rapid release of lidocaine through volume expansion of its core AMs after full absorption of water. The release equilibrium of lidocaine was reached rapidly in 18 min. CPAMs could quickly coagulate blood within 60 s, and its coagulation performance was better than Band-Aids. Conclusion: CPAMs is a kind of fast releasing dressings with good performance.