Nogo-B在缺氧诱导心肌细胞肥大中的表达变化研究*
he expression of Nogo-B in the cardiomyocyte hypertrophy induced by hypoxia*
本研究的目的是观察缺氧所致心肌细胞肥大过程中网状蛋白家族4-B亚族（reticulon protein family 4，Rtn4-B，即Nogo-B）的表达变化。首先在5%或2.5%氧浓度条件下培养H9c2心肌细胞诱导心肌细胞发生肥大表型转变后观察Nogo-B表达变化；其次在2.5%氧浓度下分别培养H9c2细胞2h、4h、8h、16h、24h后观察Nogo-B的水平改变情况。结果显示，2.5%及5%低氧刺激24小时，均可诱导心肌细胞发生肥大，
he aim of this study is to investigate the expression of reticulon protein family 4-B（Nogo-B）in the cardiomyocyte hypertrophy induced by hypoxia. Cultured H9c2 cardiomyocytes were exposed to different hypoxia concentration
刘小菁、李君丽、赵明月、吴文超
基础医学生理学分子生物学
医学细胞生物学Nogo-B缺氧心肌细胞肥大
Medical cell biologyNog-BHypoxiaardiomyocyte hypertrophy
刘小菁,李君丽,赵明月,吴文超.Nogo-B在缺氧诱导心肌细胞肥大中的表达变化研究*[EB/OL].(2016-06-27)[2025-06-27].http://www.paper.edu.cn/releasepaper/content/201606-879.点此复制
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