Differences in cortical surface area in developmental language disorder
Differences in cortical surface area in developmental language disorder
ABSTRACT Approximately seven per cent of children have developmental language disorder (DLD), a neurodevelopmental condition associated with persistent language learning difficulties without a known cause. Our understanding of the neurobiological basis of DLD is limited. Here, we used FreeSurfer to investigate cortical surface area and thickness in 54 children and adolescents with DLD and 74 age-matched controls aged 10-16 years. We also examined cortical asymmetries in DLD using an automated surface-based technique. Those with DLD showed smaller surface area bilaterally in the inferior frontal gyrus extending to the anterior insula, in the posterior temporal and ventral occipito-temporal cortex, and in portions of the anterior cingulate and superior frontal cortex. There were no differences in cortical thickness, nor in asymmetry of these cortical metrics. Post-hoc exploratory analyses revealed that surface area in the left fusiform and inferior frontal cortex related to children’s reading and non-word repetition scores, respectively. This study highlights the importance of distinguishing between surface area and cortical thickness in investigating the brain basis of neurodevelopmental disorders and suggests the development of cortical surface area to be of importance to DLD. Future longitudinal studies are required to understand the developmental trajectory of these cortical differences in DLD and how they relate to language maturation.
Krishnan Saloni、Healy M¨￠ir¨|ad P、Cler Gabriel J、Smith Harriet J、Willis Hanna E、Bahar Nilgoun、Watkins Kate E、Asaridou Salomi S
Department of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of Oxford||Department of Psychology, Royal Holloway, University of LondonDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of Oxford||Department of Psychology, University of CambridgeDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of Oxford||Department of Speech & Hearing Sciences, University of WashingtonDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of Oxford||MRC Cognition & Brain Sciences Unit, University of CambridgeDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of Oxford||Nuffield Department of Clinical Neuroscience, University of OxfordDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of OxfordDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of OxfordDepartment of Experimental Psychology & Wellcome Trust Centre for Integrative Neuroimaging, University of Oxford
神经病学、精神病学基础医学医学研究方法
Developmental language disorderpaediatricstructural MRIsurface-based anatomical modellingstructural asymmetrysurface area
Krishnan Saloni,Healy M¨￠ir¨|ad P,Cler Gabriel J,Smith Harriet J,Willis Hanna E,Bahar Nilgoun,Watkins Kate E,Asaridou Salomi S.Differences in cortical surface area in developmental language disorder[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2023.07.13.548894.点此复制
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