PDCD4和Ki67蛋白在胃肠道间质瘤中的表达

o explore the expression of programmed cell death 4 (PDCD4) and Ki67 in Gastrointestinal stromal tumors (GISTs). Methods PDCD4 expression in 20 specimens of Gastrointestinal stromal tumors and relevant adjuvant non-cancerous tissue were detected by RT-PCR; immunohistochemistry was used to examine the expression of PDCD4 and Ki67. Results We found that the expression of PDCD4 mRNA and protein are lost or decreased in 70% (14/20) of tumor samples, whereas adjacent normal gastrointestinal tissues expressed high levels of PDCD4 mRNA and protein. Moreover, the Ki-67 labeling index (Ki-67 LI) from PDCD4 abnormal expression group（5.21±4.04）of GISTs was significantly higher than that from normal patients（1.67±1.03）（p < 0.01）. PDCD4 expression had a strong negative correlation with Ki-67 labeling index (r = -0.8237, P < 0.0001). Conclusions PDCD4 expression was downregulated in human gastrointestinal stromal tumors, which may contribute to the malignant development of the tumor.