妊娠期糖尿病孕妇酮体、肌醇含量变化与胎儿畸形的相关性

Objective To understand GDM women ketones and inositol content changes and fetal deformity correlation toachieve in the first trimester of fetal malformations for the purpose of prevention. Methods Gestational diabetes (GDM) andpregnant women giving birth in hospital outputs 19 patients with fetal malformations collected from January 2010 to June 2013in our hospital were set as GDM group. 19 cases with routine examination and normal healthy pregnan were set as controlgroup. Study groups within 3 months of pregnancy when measured in vivo ketone, inositol and fasting blood glucose levelsand tracking statistics fetal malformation type analysis GDM women ketones and inositol content change effects on fetaldeformity. Results Subjects in age, gestational age, BMI and other general information had no significant difference (P>0.05).After an analysis for the detection of indicators found, GDM group of pregnant women ketones and fasting plasma glucoselevels were significantly higher, while the levels of inositol lower than the control group. The difference between the twogroups was statistically significant (P<0.05). GDM group of pregnant women delivered a major fetal malformations or withoutbrain child, spina bifida, kidney malformations and other central nervous system defects. Conclusion GDM women ketonelevels and inositol metabolism can affect the normal development of the fetus in the first trimester of fetal malformationsforecast whether there has a certain value, as a possible indicator for gestational diabetes in pregnant women clinically timelyremedy or termination of pregnancy to reduce the incidence of fetal malformations.