基于静电纺丝的可控纳米纤维生物支架的制造方法

the natural extracellular matrix (ECM) provides moderate growing conditions for the cells with the characteristic of nano fibrous structure, which plays an important role in maintaining the bioactivity and physiological function. By mimicking the nano fibrous structure of the ECM, the biological scaffold is a significant method to repair the tissue and organ. While for some tissue with oriented structures like nerve, vessel and muscle, the scaffold should possess regular nanostructures to guide the cells' proliferation and arrangement and ensure the physiological function. Although the traditional electrospinning owns the advantage in obtaining nano fibrous structures, the scaffolds gained in this way were just disordered nano fibrous membranes because of the bending instability and the Coulomb interactions between the jets. Aiming to improve the controllability of the jets in the electrospinning process, the latest electrospinning-based fabrications of biological scaffold with controllable nanofiber were reviewed. The advantages and disadvantages of these methods were discussed to provide reference for the fabrication of biological scaffold with controllable nanofiber in the future.