Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China
Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne arbovirus that can cause bleeding and death in humans. The mortality rate in humans is between 5 to 30%. The pathogen is prevalent in more than 30 countries in the world. In China, reports of strains of CCHFV have been concentrated in Xinjiang province. However, the CCHFV strain has never been reported in Inner Mongolia, China. This study reports new CCHFV strains, HANM-18, from Hyalomma asiaticum and Hyalomma dromedarii collected in Alxa Left Banner and Alxa Right Banner in Inner Mongolia. Complete sequences of CCHFV were obtained by the nested PCR technique and used for analyzing the identity and evolutionary relationship with other CCHFV strains. Interestingly, our results showed that the S and L fragments of the HANM-18 strain had high degrees of identity with Xingjiang isolate strains, and the M fragment had significant identity with South African isolates. These analyses also indicate that the HANM-18 strain may have been prevalent in northwest Inner Mongolia for many years. This discovery will be helpful in CCHF prevention and control in Inner Mongolia, and it also adds new evidence to the epidemiology of CCHF in China.
Yan Chao、Li Yong、Liu Xiaodong、Kong Yunyi、Zhang Gang、He Biao、Jiang Lingling
School of life science, Ningxia UniversityKey Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in the Western China, Ningxia University||School of life science, Ningxia UniversitySchool of life science, Ningxia UniversityKey Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in the Western China, Ningxia University||School of life science, Ningxia UniversitySchool of life science, Ningxia UniversityKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Academy of Military SciencesSchool of life science, Ningxia University
基础医学微生物学预防医学
Inner MongoliaCrimean Congo hemorrhagic fever virusphylogenetic analysis
Yan Chao,Li Yong,Liu Xiaodong,Kong Yunyi,Zhang Gang,He Biao,Jiang Lingling.Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China[EB/OL].(2025-03-28)[2025-07-21].https://www.biorxiv.org/content/10.1101/2021.06.06.447231.点此复制
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