Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2
Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2
Abstract In 2013, two new avian influenza viruses (AIVs) H7N9 and H10N8 emerged in China caused worldwide concerns. Previous studies have studied their originations independently; this study is the first time to investigate their co-originating characteristics. Gene segments of assorted subtype influenza A viruses, as well as H10N8 and H7N9, were collected from public database. 26 With the help of series software, small and large-scale phylogenetic trees, mean evolutionary rates, and divergence years were obtained successionally. The results demonstrated the two AIVs co-originated from H9N2, and shared a spectrum of mutations in common on many key sites related to pathogenic, tropism and epidemiological characteristics. For a long time, H9N2 viruses had been circulated in eastern and southern China; poultry was the stable and lasting maintenance reservoir. High carrying rate of AIVs H9N2 in poultry had an extremely high risk of co-infections with other influenza viruses, which increased the risk of virus reassortment. It implied that novel AIVs reassortants based on H9N2 might appear and prevail at any time in China; therefore, surveillance of H9N2 AIVs should be given a high priority.
Chen Liang、Chen Yue、Jiang Qingwu、Zhang Zhijie、Zhao Genming、Xiong Chenglong、Li Rui、Zhu Feng、Jiang Lufang
Department of Sanitary Microbiology, School of Public Health, Fudan University||Key Laboratory of Public Health Safety, Ministry of Education, ShanghaiDepartment of Epidemiology and Community Medicine, Faculty of Medicine, University of OttawaKey Laboratory of Public Health Safety, Ministry of Education, Shanghai||Department of Epidemiology and Biostatistics, School of Public Health, Fudan UniversityKey Laboratory of Public Health Safety, Ministry of Education, Shanghai||Department of Epidemiology and Biostatistics, School of Public Health, Fudan UniversityKey Laboratory of Public Health Safety, Ministry of Education, Shanghai||Department of Epidemiology and Biostatistics, School of Public Health, Fudan UniversityDepartment of Sanitary Microbiology, School of Public Health, Fudan University||Key Laboratory of Public Health Safety, Ministry of Education, ShanghaiKey Laboratory of Public Health Safety, Ministry of Education, Shanghai||Department of Epidemiology and Biostatistics, School of Public Health, Fudan UniversityDepartment of critical care medicine, the first affiliated hospital of Nanchang UniversityDepartment of Sanitary Microbiology, School of Public Health, Fudan University||Key Laboratory of Public Health Safety, Ministry of Education, Shanghai
医药卫生理论医学研究方法微生物学
Avian Influenza VirusH10N8H7N9China
Chen Liang,Chen Yue,Jiang Qingwu,Zhang Zhijie,Zhao Genming,Xiong Chenglong,Li Rui,Zhu Feng,Jiang Lufang.Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2[EB/OL].(2025-03-28)[2025-05-15].https://www.biorxiv.org/content/10.1101/004390.点此复制
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