The association between cancer and spousal rate of memory decline: a negative control study to evaluate (unmeasured) social confounding of the cancer-memory relationship
The association between cancer and spousal rate of memory decline: a negative control study to evaluate (unmeasured) social confounding of the cancer-memory relationship
Abstract Cancer diagnoses are associated with better long-term memory in older adults, possibly reflecting a range of social confounders that increase cancer risk but improve memory. We used spouse’s memory as a negative control outcome to evaluate this possible confounding, since spouses share social characteristics and environments, and individuals’ cancers are unlikely to cause better memory among their spouses. We estimated the association of an individual’s incident cancer diagnosis (exposure) with their own (primary outcome) and their spouse’s (negative control outcome) memory decline in 3,601 couples from 1998-2014 in the Health and Retirement Study, using linear mixed-effects models. Incident cancer predicted better long-term memory for the diagnosed individual. We observed no association between an individual’s cancer diagnosis and rate of spousal memory decline. This negative control study suggests that the inverse association between incident cancer and rate of memory decline is unlikely to be attributable to social/behavioral factors shared between spouses.
Graff Rebecca E.、Ackley Sarah、Kobayashi Lindsay C.、Ospina-Romero Monica、Glymour M. Maria、Mayeda Elizabeth R.、Lu Kun Ping、Witte John S.、Brenowitz Willa D.
Department of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Epidemiology, School of Public Health, University of MichiganDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Epidemiology and Biostatistics, University of California San FranciscoJonathan and Karin Fielding School of Public Health, University of California Los AngelesDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Psychiatry, University of California San Francisco
医学研究方法肿瘤学神经病学、精神病学
CancerAlzheimer’s diseaseagingcognitive impairmentcognitive declineepidemiologymemory scoresnegative control study
Graff Rebecca E.,Ackley Sarah,Kobayashi Lindsay C.,Ospina-Romero Monica,Glymour M. Maria,Mayeda Elizabeth R.,Lu Kun Ping,Witte John S.,Brenowitz Willa D..The association between cancer and spousal rate of memory decline: a negative control study to evaluate (unmeasured) social confounding of the cancer-memory relationship[EB/OL].(2025-03-28)[2025-06-06].https://www.medrxiv.org/content/10.1101/2020.02.24.20027516.点此复制
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