Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson’s Disease
Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson’s Disease
Abstract BackgroundEpidemiological studies have reported association between Parkinson’s disease (PD) and restless legs syndrome (RLS). ObjectivesWe aimed to use genetic data to study whether these two disorders are causally linked or share genetic architecture. MethodsWe performed two-sample Mendelian randomization (MR) and linkage disequilibrium score regression (LDSC) using summary statistics from recent genome-wide meta-analyses of PD and RLS. ResultsWe found no evidence for a causal relationship between RLS (as the exposure) and PD (as the outcome, inverse variance-weighted; b=-0.003, se=0.031, p=0.916, F-statistic=217.5). Reverse MR also did not demonstrate any causal effect of PD on RLS (inverse variance-weighted; b=-0.012, se=0.023, p=0.592, F-statistic=191.7). LDSC analysis demonstrated lack of genetic correlation between RLS and PD (rg=-0.028, se=0.042, p=0.507). ConclusionsThere was no evidence for a causal relationship or genetic correlation between RLS and PD. The associations observed in epidemiological studies could be, in part, attributed to confounding or non-genetic determinants.
Yu Eric、Varghaei Parizad、Noyce Alastair J、Rouleau Guy A、Estiar Mehrdad A、Senkevich Konstantin、Gan-Or Ziv、Krohn Lynne、Bandres-Ciga Sara
Department of Human Genetics, McGill University, Montr¨|al||The Neuro (Montreal Neurological Institute-Hospital), McGill UniversityThe Neuro (Montreal Neurological Institute-Hospital), McGill University||Division of Experimental Medicine, Department of Medicine, McGill UniversityPreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London||Department of Clinical and Movement Neurosciences, UCL Institute of NeurologyDepartment of Human Genetics, McGill University, Montr¨|al||The Neuro (Montreal Neurological Institute-Hospital), McGill University||Department of Neurology and Neurosurgery, McGill University, Montr¨|al, Qu¨|becDepartment of Human Genetics, McGill University, Montr¨|al||The Neuro (Montreal Neurological Institute-Hospital), McGill UniversityThe Neuro (Montreal Neurological Institute-Hospital), McGill University||Department of Neurology and Neurosurgery, McGill University, Montr¨|al, Qu¨|becDepartment of Human Genetics, McGill University, Montr¨|al||The Neuro (Montreal Neurological Institute-Hospital), McGill University||Department of Neurology and Neurosurgery, McGill University, Montr¨|al, Qu¨|becDepartment of Human Genetics, McGill University, Montr¨|al||The Neuro (Montreal Neurological Institute-Hospital), McGill UniversityLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
神经病学、精神病学医学研究方法基础医学
Restless legs syndromeParkinson’s diseaseMendelian randomizationlinkage disequilibrium score regressiongenetic correlation
Yu Eric,Varghaei Parizad,Noyce Alastair J,Rouleau Guy A,Estiar Mehrdad A,Senkevich Konstantin,Gan-Or Ziv,Krohn Lynne,Bandres-Ciga Sara.Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson’s Disease[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2021.02.16.21251687.点此复制
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