转录因子Snail与肺纤维化关系的研究进展

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins. Recent researches show that TGF-βinduced epithelial-mesenchymal transition(EMT) plays an important role in pulmonary fibrosis. Snail can induce the EMT and promote fibrosis．In addition, Snail can affect the fibrosis progression through immune regulation and cell apoptosis resisting. This paper reviews the structure of the Snail, its function, and signaling pathway, also, the relationship between snail's immune regulation, cell apoptosis affect and pulmonary fibrosis.