围产期缺氧缺血性脑损伤动物模型的研究进展

nimal models are often the first step in determining mechanisms underlying disease, and the approach and effectiveness of therapeutic interventions. Despite marked advances in our understanding of these processes and numerous animal models have been used to study term infants and preterm children with brain injury . However, controversy continues over which animal model can refect human disease states,and whether the therapies that we now providing are benefit than harm. This review introduces the process of neonatal brain development , and focuses on discussing commonly used models of hypoxic-ischemic injury in the newborn brain.