路易斯酸催化下环丙烷1,1-双酯的分子间[3＋2]环加成反应
LA-Cat Intermolecular [3+2] Cycloadditions of Cyclopropane 1,1-Diesters
五员碳/杂环骨架（如：环戊烷，四氢呋喃和四氢吡咯等）广泛存在于天然产物中，因此关于该类骨架的新颖、高效的合成方法学研究一直以来受到合成化学家的关注。环丙烷1,1-双酯近年来受到了广泛的重视。该类分子易制备，且在路易斯酸催化下与C=C, C=O和C=N等发生[3+2]环加成反应构筑五员碳/杂环骨架。本文将综述环丙烷1,1-双酯的各类型[3+2]环加成反应及其在天然产物的全合成中的应用。
5-Membered carbo-/heterocyclic rings (e.g. cyclopentane, tetrahydrofuran and tetrahydropyrrole) broadly exist in natural products, and their novel and efficient construction have attacted great attentions from synthetic chemists. Cyclopropane 1,1-diesters can be easily prepared and can be used for construction of 5-membered carbo-/heterocyclic rings via [3+2] cycloadditions with C=C, C=O and C=N under catalysis of Lewis acids. In this paper，we review the intermolecular [3+2] cycloadditions of cyclopropane 1,1-diesters, and their applications in total synthesis of natural products.
王忠文、房杰
有机化学工业制药化学工业
农药学有机合成环丙烷环加成天然产物合成
pesticideorganic synthesiscyclopropanecycloadditionsynthesis of natural products
王忠文,房杰.路易斯酸催化下环丙烷1,1-双酯的分子间[3＋2]环加成反应[EB/OL].(2011-02-24)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/201102-648.点此复制
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