家兔髋脱位模型中髋臼软骨病理改变研究

Objective To invest the pathologic changes in the acetabular cartilage of dislocated hip. Methods Using HE staining to view pathohistologic features of dysplastic acetabulum harvested from the disclocated or dysplastic hip of rabbit model which has been verified by the X-ray film. Apoptotic bodies and their distribution in the cartilage was observed by using terminal deoxynucleotidyl transferase Dutpnick-end labeling(TUNEL) staining. Results After 8 week of fixation of extended knee in rabbit, the fixation side of hip was induced dysplasia or dislocation of hip. The acetabular index was increased in dysplastic hip than contralateral hip (P<0.05). In acetabular cartilage of the control side, the apoptotic bodies widely distributed in hypertrophic zone, and some in proliferating zone, only few scattered in resting zone. In dysplastic side of the hip, acetabular cartilage contained only a few apoptotic bodies in the resting zone and superficial of proliferating zone. Conclusion The amount of apoptotic chondrocyte in acetabular cartilage of dysplastic hip was much fewer than that in the control side. The decreasing of the apoptosis in hypertrophic zone of the dysplastic acetabulum maybe causes the thickening in acetabular cartilage of the displastic hip.