再生丝素蛋白/P(LLA-CL)皮芯结构复合纳米纤维膜制备和性能研究

In this paper, silk fibroin/P(LLA-CL) core-shell structured composite nanofibers membrane was fabricated by coaxial electrospinning of P(LLA-CL)/SF solutions dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol(HFIP). The morphology, mechanical properties and biocompatibility of of P(LLA-CL)/silk fibroin shell-core structured composite nanofibers were investigated by FE-SEM, TEM, Multi-Purpose Tensile Tester and MTT assay. The results show that the coaxial electrospun nanofibers diameter decrease with the increase of SF or P(LLA-CL) content. The mechanical characterization of coaxial electrospun nanofibers tend to increase with he increase of P(LLA-CL) content. The biocompatibility of the coaxial electrospun nanofibers membrane was better than that of pure SF or P(LLA-CL).It comes to find the best concentration of shell and core is 8%(w/w) and 2%(w/w) respectively.