微流芯片制备粒径均一的纤维素微球

Ionic liquid, [EMIM]MP, was used to dissolve the microcrystalline cellulose, and the cellulose solution was dispersed by the microfluidic chip to prepare the cellulose beads with uniform size. The effects of cellulose solution, flow rates of oil phase and water phase were investigated. The optimized preparation condition was 2% cellulose solution as water phase, the flow rate of water phase of 5~10 μl/min and oil phase of 200~400 μl/min. The microdroplets of cellulose solution could be obtained at the range of 100～200 μm with the variation coefficient less than 0.2. After solidification and regeneration, cellulose beads were obtained which showed good sphericity. The wet density was 1.012 g/ml, the porosity of beads was 96.11%, and the mean size was about 25 μm, which showed a potential application as the chromatographic matrix.