大剂量辛伐他汀导致大鼠骨骼肌形态学的改变

Statins are the most popular lipid-lowering drug due to its effect on cholesterol control. But clinical reports on its adverse effects are gradually increasing, including statin-associated myopathy (1%-10%) and rhabdomyolysis (0.1%), and no effective prevention can be adopted. Some studies also show that exercise can increase the risk of statin-associated myopathy. Until now, the mechanism underlying statin-associated myopathy is unknown. Statins inhibit mevalonate pathway could lead to the inhibition of coenzyme Q10 synthesis on mitochondrial inner membrane, which may cause mitochondrial oxidative respiratory dysfunction, free radical increase and mitochondrial apoptosis pathway up-regulation. In this study we use hyperlipidemia rat model to investigate the skeletal muscle morphological changes due to high-dose simvastatin.The study on statin-associated myopathy could contribute to the development of prevention drugs.