淋巴细胞计数对社区获得性肺炎患者细胞免疫功能的判断价值

Objective To investigate the value of lymphocyte count in assessing cellular immune function in patients with community-acquired pneumonia. Methods Ninety-three patients with community-acquired pneumonia (including 53 non-severe and 40 severe cases) and 52 healthy adults were examined for routine blood test and T lymphocyte count. Blood lymphocyte counts and absolute T lymphocyte counts were compared among the 3 groups and their correlation was analyzed. Results Compared with the healthy control subjects, patients with community-acquired pneumonia showed significantly lower blood lymphocyte counts and CD3 + , CD4 + , and CD8 + levels (P<0.05). CD3 + , CD4 + , and CD8 + levels were positively correlated with blood lymphocyte counts. With blood lymphocyte count as the independent variable (L), and the regression equations for CD3 + , CD4 + , and CD8 + levels were CD3 + =485.45 L +313.48 (F=59.68, P<0.01), CD4 + =192.57 L +290.11 (F=24.62, P<0.01),and CD8 + =275.14 L +18.04 (F=23.46, P<0.01) in the control group; CD3 + =564.15 L +25.04 (F=96.56, P<0.01), CD4 + =381.91L-37.45 (F=68.60, P<0.01), and CD8 + =165.61 L +61.83 (F=55.47, P<0.01) in non-severe pneumonia group; and CD3 + =565.44 L +49.09 (F=31.87, P<0.01), CD4 + =332.34 L -17.37 (F=43.64, P<0.01), and CD8 + =223.46 L +54.39 (F=13.90, P<0.01) in severe pneumonia group. Conclusion Patients with community-acquired pneumonia have decreased cellular immune function. Absolute T lymphocyte count can be estimated by blood lymphocyte count to save the cost of laboratory tests.