早产儿视网膜病变病理调控机制研究进展

Retinopathy of prematurity (ROP)is a refractory disease in the field of ophthalmology. It is characterized by serious damage to visual function, including reduced contrast and sensitivity, visual field defects, color vision defects, strabismus and refractive errors. In serious cases, children with ROP could suffer from lifelong blindness. In-depth research of the specific pathological mechanism of ROP has important scientific value and clinical significance for prevention, treatment and prognosis of ROP. In the recent years, research on the mechanism of ROP has become a hotspot. This article will focuses on the pathological mechanisms in the development and progression of ROP，and provide a brief overview around the following aspects:angiogenesis,immune inflammation,apoptosis,oxidative stress and non-coding RNA.