柠檬酸钠对小鼠生理及肠道微生物的影响

Effects of sodium citrate on physiology and intestinal flora of mice were investigated in this research. Mice were randomly divided into four groups:control group, low-dose group(0.65% sodium citrate), middle-dose group(2.6%) and high-dose group(5.2%).The diet intervention lasted for four weeks. The stool samples and weight data were collected weekly, the composition of intestinal microbiota and the serum biochemical indicators were determined at the end of the fourth week. The results showed that the high dose of sodium citrate had an impact on the body weight and the concentration of high density lipoprotein cholesterol (HDL-C). The beta diversity and the ratio of Fimicutes to Bacteriodetes were changed by intake of sodium citrate. Corynebacterium and Staphylococcus were detected in the high-dose group. Results indicated that the intestinal flora of mice could be affected by intake of high dose of sodium citrate.