静电纺丝制备药物载体
onstruction of Drug Carrier by Electrospinning
为了能够提高药物释放载体的效率，文中使用电纺丝技术进行纳米通道系统的构建。通过实验摸索得到的纺丝条件。将聚苯乙烯（PS：90000MW）材料在20kV的电压下，由溶液质量分数5%，纺得了直径为200 nm的纤维。经过在玻璃化温度下加热粘连后，使用硅橡胶(PDMS)灌注，形成与聚苯乙烯复合的网络材料。再使用二硫化碳溶液浸泡超声，将内部PS溶掉，最终得到内部含有微米直径的药物载体系统。
In order to improve the efficiency of drug delivery carriers, nano-channel System was constructed utilyzing electrospinning technology. Polystyrene fibers with diameter of 200 nm could be successfully fabricated in the voltage of 20kV, the solution concentration 5%. After heating the network at the glass transition temperature of PS for a while, PS fibers could be adhesive for each other. Perfusion and solidation of the silicone rubber (PDMS) into the PS networks, we could obtain a kind of composite material. After immersion and ultrasound of the component material in the carbon disulfide solution, internal PS solved. Finally a channel system formed.
徐松秀、李良彬、王寅宁
药学材料科学高分子化合物工业
米材料静电纺丝聚苯乙烯硅橡胶药物载体
nanomaterialelectrospinningpolystyrenePDMSdrug carrier
徐松秀,李良彬,王寅宁.静电纺丝制备药物载体[EB/OL].(2011-11-22)[2025-08-03].http://www.paper.edu.cn/releasepaper/content/201111-347.点此复制
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