Cannabis use and risk of type 2 diabetes: a two-sample Mendelian randomization study
Cannabis use and risk of type 2 diabetes: a two-sample Mendelian randomization study
Abstract Cannabis has effects on the insulin/glucose metabolism. As the use of cannabis and the prevalence of type 2 diabetes increase worldwide, it is important to examine the effect of cannabis on the risk of diabetes. We conducted a Mendelian randomization study by using 19 single-nucleotide polymorphisms as instrumental variables for lifetime cannabis use and 14 SNPs to instrument cannabis use disorder, and linking these to type 2 diabetes risk using genome-wide association study data (lifetime cannabis use [N = 184,765]; cannabis use disorder [2,387 cases / 48,985 controls], type 2 diabetes [74,124 cases / 824 controls]). The MR analysis suggested no effect of lifetime cannabis use (inverse variance weighted odds ratio [95% confidence interval] = 1.00 [0.93-1.09], P-value = 0.935) and cannabis use disorder (OR = 1.03 [0.99-1.08]) on type 2 diabetes. Sensitivity analysis to assess potential pleiotropy led to no substantive change in the estimates. This study adds to the evidence base that cannabis use does not play a causal role in type 2 diabetes.
Baumeister Sebastian-Edgar、Leitzmann Michael、Alayash Zoheir、Nolde Michael、Meisinger Christa、Baurecht Hansj?rg
Chair of Epidemiology, LMU M¨1nchen, UNIKA-T Augsburg||Independent Research Group Clinical Epidemiology, Helmholtz Zentrum M¨1nchen, German Research Center for Environmental HealthDepartment of Epidemiology and Preventive Medicine, University of RegensburgChair of Epidemiology, LMU M¨1nchen, UNIKA-T AugsburgChair of Epidemiology, LMU M¨1nchen, UNIKA-T Augsburg||Independent Research Group Clinical Epidemiology, Helmholtz Zentrum M¨1nchen, German Research Center for Environmental HealthChair of Epidemiology, LMU M¨1nchen, UNIKA-T Augsburg||Independent Research Group Clinical Epidemiology, Helmholtz Zentrum M¨1nchen, German Research Center for Environmental HealthDepartment of Epidemiology and Preventive Medicine, University of Regensburg
医学研究方法医药卫生理论内科学
cannabisdiabetes
Baumeister Sebastian-Edgar,Leitzmann Michael,Alayash Zoheir,Nolde Michael,Meisinger Christa,Baurecht Hansj?rg.Cannabis use and risk of type 2 diabetes: a two-sample Mendelian randomization study[EB/OL].(2025-03-28)[2025-07-16].https://www.medrxiv.org/content/10.1101/2020.09.21.20197343.点此复制
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